Breaking the Chain: How Brown University is Leading the Charge in Research for Opioid Overdose Prevention

The opioid crisis in the United States has been ongoing since the mid-1990s and has significantly affected public health, the nation’s economy, and social outcomes. More than 500,000 opioid-related deaths have occurred since 2000, making the United States the country with the highest number of opioid-involved deaths per capita. Opioid overdose deaths were among the leading causes of death in 2020. The crisis has been marked by waves distinguished by the types of opioids involved in overdose deaths and the use of opioids in combination with other drugs. The use and misuse of opioids can lead to serious health effects, including opioid use disorder (OUD), which can affect people’s participation in the labor force and their ability to care for their children. Furthermore, the COVID-19 pandemic exacerbated the opioid crisis as opioid misuse increased due to worsened mental health, social isolation, job losses, and reduced access to treatment.

There have been various strategies and programs implemented to address the opioid crisis:

  1. Federal Laws: Between 2016 and 2018, three laws were enacted to lower the demand for and supply of opioids and reduce their harm. These laws provided funding to agencies tasked with responding to substance use disorders, including opioid use disorder.
  2. Prescription Drug Monitoring Programs (PDMPs): PDMPs are electronic databases that track controlled substance prescriptions within a state. They can provide health authorities with timely information about prescribing and patient behaviors that contribute to the epidemic, facilitate targeted responses, and help healthcare providers make informed prescribing decisions. States have taken steps to make PDMPs easier to use and access, such as integrating them into electronic health record systems and implementing policies that require providers to check PDMPs before prescribing certain controlled substances.
  3. Safe Injection Sites and Research at Brown University: For the first time, the U.S. government funded a large study to measure whether overdoses can be prevented by safe injection sites, places where people can use heroin and other narcotics under supervision and be revived if they overdose. The study, funded with more than $5 million over four years, is being conducted by New York University and Brown University. The researchers hope to enroll 1,000 adult drug users to study the sites’ effects on overdoses, estimate their costs, and gauge potential savings for healthcare and criminal justice systems. The grant marks a move by the U.S. government toward what is known as harm reduction, a strategy focused on preventing death and illness in drug users while helping them get care, as opposed to punishment. This research at Brown University and its partner institution is crucial in providing data to evaluate the effectiveness and impact of safe injection sites on the community.
  4. Harm Reduction Research Network: The National Institutes of Health established a harm reduction research network in December to study programs providing services and supplies such as naloxone (a drug that can reverse overdoses) and materials to test drugs for fentanyl, which is a powerful opioid that has been driving record numbers of overdoses.
  5. International Approaches: In addition to strategies employed within the U.S., other countries have implemented different approaches to manage their own opioid crises. Safe injection sites, for example, operate in 14 countries including Canada, Australia, and France. The U.S. has been observing and learning from these international practices.

It’s important to note that addressing the opioid crisis requires a multifaceted approach that includes not just government initiatives, but also the involvement of healthcare providers, communities, and individuals. Education, awareness, access to treatment, and support for those struggling with addiction are crucial components of any successful strategy to combat the opioid crisis.

The research being conducted at Brown University, in particular, represents a significant development in the ongoing efforts to address the opioid crisis. By studying the effects of safe injection sites on overdoses and evaluating their costs and potential savings for healthcare and criminal justice systems, this research can provide valuable data that will inform policy decisions. Safe injection sites are a relatively new approach in the United States, and understanding their impact is crucial for assessing whether they should be more widely implemented as part of a harm reduction strategy.

Dr. Nora Volkow, director of the National Institute on Drug Abuse, emphasized the importance of data in evaluating the efficacy of overdose prevention centers. She stated, “There is a lot of discussion about overdose prevention centers, but ultimately, we need data to see if they are working or not, and what impact they may have on the community”.

By focusing on harm reduction and researching innovative approaches like safe injection sites, institutions like Brown University play a crucial role in the evolving response to the opioid crisis. Their research could lead to new insights and strategies that save lives and improve the well-being of individuals and communities affected by opioid addiction.

In conclusion, the opioid crisis is a complex and multifaceted public health issue that demands a similarly complex and multifaceted response. From federal policies and prescription drug monitoring programs to innovative harm reduction approaches and research conducted by institutions such as Brown University, an array of strategies are being employed to combat the crisis. It is imperative that these efforts continue to evolve based on evidence and that they are supported by adequate funding and public awareness. The research at Brown University represents one of the many essential steps in the pursuit of effective solutions to this ongoing crisis.

  1. Congressional Budget Office. (n.d.). The Opioid Crisis and Recent Federal Policy Responses. Retrieved from https://www.cbo.gov/publication/57345
  2. Centers for Disease Control and Prevention. (n.d.). Prescription Drug Monitoring Programs (PDMPs). CDC Injury Center. Retrieved from https://www.cdc.gov/drugoverdose/pdmp/index.html
  3. Associated Press. (2023). US backs study of safe injection sites, overdose prevention. AP News. Retrieved from https://apnews.com/article/health-education-new-york-new-york-city-coronavirus-pandemic-32c85a7099ecea52a9db2fcf050c3d01